One in 100 people has bipolar disorder

A drug currently used to treat schizophrenia could also help millions of people
with
manic depression.

Results from a major clinical trial suggest quetiapine is an effective treatment
for
those with bipolar disorder.

The drug, which is manufactured by AstraZeneca, and sold under the brand name
Seroquel, works well if it is used in combination with mood stabilising
medication.

It might become another option for people who have bipolar disorder
Dr Tony Cleare, Institute of Psychiatry

Experts said the trial paved the way for the drug to be used as an alternative
treatment for people with manic depression.

Professor Gary Sachs from Harvard Medical School in the United States who headed
the study said the drug was more effective than some existing treatments.

Existing drugs

"Current treatment options for patients with bipolar disorder are limited.
Commonly
used therapies involving mood stabilisers are not effective for all patients and
can be
associated with troublesome side effects," he said.

"As a result patient compliance with treatment can be a real challenge. This is
particularly critical in bipolar disorder since patients typically lead full
lives with jobs
to hold down and valuable relationships to maintain."

Professor Sachs added that the drug was effective in reducing symptoms of
bipolar
disorder.

"The results show not only that quetiapine is effective in treating bipolar
disorder and
the manic symptoms often associated with it, but also that more patients treated
with
quetiapine experienced a full resolution of their manic symptoms compared to
patients taking mood stabilisers alone.

"This impressive efficacy combined with the excellent tolerability profile that
quetiapine exhibited throughout the trial, suggest that it is an important and
valuable
new weapon in our fight against this problematic disease."

However, AstraZeneca will first have to seek regulatory approval to enable
doctors to
prescribe quetiapine to patients with the disorder.

Alternative

Nevertheless, Dr Anthony Cleare a senior lecturer at the Institute of Psychiatry
in
London and a consultant psychiatrist welcomed the results of the clinical trial.

He told BBC News Online: "The important thing is that for patients who are
reporting
side-effects from other medication this will provide an alternative.

"It might become another option for people who have bipolar disorder."

Bipolar disorder is a severe mental illness that affects more than 1% of the
adult
population.

This figure is starting to rise as more and more patients are being diagnosed
properly. A high proportion of patients with the condition attempt suicide.

The results of the clinical trial were presented at the third European Stanley
Foundation Conference on Bipolar Disorder in Freiburg in Germany.