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Like other imidazole- and triazole-class antifungals, fluconazole inhibits the fungal cytochrome P450 enzyme demethylase. Mammalian demethylase activity is much less sensitive to fluconazole than fungal demethylase. This inhibition prevents the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane, and subsequent acc'umulation of methyl sterols Fluconazole is primarily fungistatic, however may be fungicidal against certain organisms in a dose-dependent manner.
Like other imidazole- and triazole-class antifungals, fluconazole inhibits the fungal cytochrome P450 enzyme demethylase. Mammalian demethylase activity is much less sensitive to fluconazole than fungal demethylase. This inhibition prevents the conversion of lanosterol to ergosterol, an essential component of the fungal cytoplasmic membrane, and subsequent acc'umulation of methyl sterols Fluconazole is primarily fungistatic, however may be fungicidal against certain organisms in a dose-dependent manner.