Dear Sir,

Thank you for your prompt response. We have prepared sustained release matrices
of using gelucire by melt solidification. But on ageing we find enhace ageing.
It may be due to convergion of triglycerides (gelucire) to more stable polymorph
of gelucire. We have confirmed these changes by Hotstagepolarizing microscopy,
Differential Scanning calorimetery etc. In this study we observed that
crystallinity increases during ageing. When we add the glyceryl monosteates
(different grades) than we observed that GMS having higher m.p. causes faster
crystallization as compared to GMS having lower m.p. which causes slower
crystallization (confirmed by DSC). Our hypothesis is that gelucire convert into
more stable polymorph rapidly deu to faster crystallization as compred to slower
crystallizations. In the first case we are able to stabilized the release
changes as compared to faster crystallization. We dont know whether we are
correct or not. Thats why we are searching any refernces regarding
the use of Nucleation enhancers in case of lipid or fat systems.

I will be highly thankfull to you if you kindly provide the xerox copy of the
Ueno, and SATO publications and a chapter of Sato book. We will acknowledge your
support in our dessertation work. We want to read in detail before we conclude
any thing.

I would like to know your affiliation and your working area.

Regards,

Bhaskar Chauhan








Bhaskar Chauhan
Senior Research Fellow,
Dept. of Pharmaceutics,
Poona College of Pharmacy,
Erandwane,
Pune-411038
Mobile no: +91 9822290326
Phone no: 91 20 5437237
Fax no: 91 20 5439383


---------------------------------
Do you Yahoo!?
Yahoo! Search - Find what you’re looking for faster.

[Non-text portions of this message have been removed]