Tramadol (INN) is an atypical opioid which is a centrally acting analgesic, used for treating mild to moderate pain. tramadol 50mg It is a synthetic agent, as a 4-phenyl-piperidine analogue of codeine, and appears to have actions on the GABAergic, noradrenergic and serotonergic systems. Tramadol was developed by the German pharmaceutical company tramadol 50mgGrunenthal GmbH and marketed under the trade name Tramal. Grunenthal has also cross licensed the drug to many other pharmaceutical companies that market it under various names. tramadol 50mg Tramadol is usually marketed as the hydrochloride salt (tramadol hydrochloride) and is available in both injectable (intravenous and/or intramuscular) and oral preparations. It is also available in conjunction with paracetamol (acetaminophen). tramadol 50mg Tramadol is approximately 10% as potent as morphine, when given by the IV/IM route. Oral doses range from 50?400 mg daily, with up to 600 mg daily when given IV/IM. The 'combination' pills each contain 37.5 mg of tramadol and 325 mg of paracetamol, with the recommended dose being one or two pills every four to six hours. tramadol 50mg Unlike most other opioids, Tramadol is not considered a controlled substance in many countries (the U.S., Canada and Australia, among others), and is available with a normal prescription. Tramadol is also available over-the-counter without prescription in a few countries.